Position: Director General, Med Biotech Laboratories

 

Contact: Med Biotech Laboratories
Muyenga Tank Hill By-pass,
Lugwana Close, Plot 3438
P.O. Box 9364, Kampala,
Uganda
Tel: +256 312 266 153
Email: doublestrand2000[at]yahoo.com

Research Interests

Major interests are in working on a new generation of drugs and vaccines that might destroy and reduce on the burden parasites that caused by malaria, schistosomiasis, giardiasis, and trypanosomiasis. He also believes in training young African scientist to the highest levels. Some of the malaria research he has been involved in includes preliminary studies on malaria during pregnancy, development of Plasmodium falciparum choline kinase inhibitors as antimalarial drugs, surveillance for antimalarial drug resistance in Plasmodium falciparum using PCR, identification and validation of molecular markers of drug resistance in the human filarial nematode parasite Onchocerca volvulus, identification and validation of biochemical drug targets in Plasmodium falciparum and Onchocerca volvulus, phospholipid metabolism, protein prenylation, and N-ethylmaleimide-sensitive fusion protein (NSF), immuno-epidemiological studies of malaria asexual blood stage vaccine antigens in Apac District, Northern Uganda

Research Projects
Current and active projects
1. Vaccine studies in Uganda: Site preparation, infrastructure development, and capacity building for clinical trials - World Bank / G.O.U. 2008 – on going

2. Research capacity for the implementation of genetic control of mosquitoes. European Commission INFRAVEC. 2009 – on going

3. Correlating protection against malaria with serum profiles against Plasmodium falciparum antigen repertoires. European Commission 218164 FIGHTMAL, 2008 – on going

4. Single blind, randomized, controlled, phase 1b study of the safety and immunogenicity of lyophilized recombinant precipitated tropical vaccine (BK-SE36) in Uganda ; BIKEN. 2009- on going

5. Bioprospecting from genomes for type II restriction enzymes, New England Biolabs USA; renewed 2008 – on going

Completed Grants

6. Molecular epidemiology of artemisinin resistance in Uganda. Uganda Malaria Research Centre/Malaria Consortium Jan-Dec 2007.

7. Molecular epidemiology of sulfadoxine-pyrimethamine resistance R03 A1059181-01 National Institutes of Health 9/01/03-8/30/07

8. Standardized low-tech laboratory assays for sustainable health care of pediatric AIDS patients in resource-poor settings and an intensive re-training program for laboratory workers in the use of these assays in Uganda. 116-04 Elizabeth Glazer Pediatric AIDS Foundation 05/01/04-04/30/07

9. HHMI International Research Scholar Award in Parasitology and Infectious Diseases 55000642 Howard Hughes Medical Institute (HHMI) 09/01/00-08/31/05

10. New genetic technologies: application to generate attenuated malaria vaccines ICA4-CT-1999-10004 European Commission 03/01/03-02/28/05

11. Pollution monitoring in the Nairobi River and Nakivubo Channel; application of new and robust biosensor technologies ICA4-CT-2002-10008 European Commission 12/01/02-05/30/06

12. Capacity building in clinical, in vitro, and molecular studies of antimalarial drug resistance in Uganda A00028 MIM/WHO/TDR 2000-2003

Selected peer-reviewed Publications